Non-natural Olefin Cyclopropanation Catalyzed by Diverse Cytochrome P450s and Other Hemoproteins
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چکیده
منابع مشابه
Non-natural olefin cyclopropanation catalyzed by diverse cytochrome P450s and other hemoproteins.
Recent work has shown that engineered variants of cytochrome P450BM3 (CYP102A1) efficiently catalyze non-natural reactions, including carbene and nitrene transfer reactions. Given the broad substrate range of natural P450 enzymes, we set out to explore if this diversity could be leveraged to generate a broad panel of new catalysts for olefin cyclopropanation (i.e., carbene transfer). Here, we t...
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Transition metal-catalyzed transfers of carbenes, nitrenes, and oxenes are powerful methods for functionalizing C=C and C-H bonds. Nature has evolved a diverse toolbox for oxene transfers, as exemplified by the myriad monooxygenation reactions catalyzed by cytochrome P450 enzymes. The isoelectronic carbene transfer to olefins, a widely used C-C bond-forming reaction in organic synthesis, has no...
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* Author for correspondence: Fatma M.A. El-garj, School of Distance Education, Universiti Sains Malaysia, 11800 Penang, Malaysia. Email [email protected]. Abstract. Cytochrome P450 monooxygenases are versatile biocatalysts that incorporate oxygen into an enormous range of molecules. The cytochrome P450 proteins are involved in the catalysis of different reactions and these properties have bee...
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ژورنال
عنوان ژورنال: ChemBioChem
سال: 2014
ISSN: 1439-4227
DOI: 10.1002/cbic.201402286